2-Chloro-N-methylpyrimidin-4-amine

Name: 2-Chloro-N-methylpyrimidin-4-amine
Brand: ChemScene
Availability: InStock
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CAS No. 66131-68-8
Cat. No. CS-0045783
Purity≥97%
MDL No.MFCD09055368

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-N-methylpyrimidin-4-amine|CS-0045783

Structure of 66131-68-8

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Description

2-Chloro-N-methylpyrimidin-4-amine features a reactive chlorine at the C2 position and a methylated nitrogen at the N1 site, enabling selective coupling in cross-coupling and nucleophilic substitution reactions. The electron-deficient pyrimidine ring enhances reactivity toward amines and thiols, while the N-methyl group improves solubility and stability under standard conditions.

Application

2-Chloro-N-methylpyrimidin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. The chloro group facilitates nucleophilic substitution reactions with amines, thiols, and other heteroatom nucleophiles, while the N-methylpyrimidin-4-amine core provides a stable, bench-stable platform for further functionalization. Its compatibility with standard coupling protocols and predictable reactivity profile make it ideal for modular synthesis of kinase inhibitors and other bioactive compounds.

General Information

CAS No. 66131-68-8
Cat. No. CS-0045783
Purity ≥97%
MDL No. MFCD09055368
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₆ClN₃
Molecular Weight 143.57
Synonym(s) 4-Pyrimidinamine, 2-chloro-N-methyl- (9CI)
SMILES CNC1=NC(Cl)=NC=C1

Computational Chemistry Data

TPSA 37.81
LogP 1.1717
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

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2-Chloro-N-methylpyrimidin-4-amine

CAS No. 66131-68-8

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