8-Chlorochroman-4-amine

Name: 8-Chlorochroman-4-amine
Brand: ChemScene
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CAS No. 770690-25-0
Cat. No. CS-0101143
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 770690-25-0

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General Information

CAS No. 770690-25-0
Cat. No. CS-0101143
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₀ClNO
Molecular Weight 183.63
Synonym(s) 8-CHLORO-CHROMAN-4-YLAMINE
SMILES NC1CCOC2=C(Cl)C=CC=C12

Description

8-Chlorochroman-4-amine features a chlorine-substituted chroman scaffold with a primary amine at the 4-position, offering enhanced electron density and improved solubility in polar solvents. This structural motif enables efficient coupling reactions in medicinal chemistry applications.

Application

8-Chlorochroman-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles through standard coupling and cyclization protocols. Its chlorinated chroman scaffold exhibits favorable bench stability and functional group tolerance, facilitating downstream modifications such as Suzuki-Miyaura couplings and amide formations. The molecule functions as a key intermediate in the synthesis of kinase inhibitors and CNS-targeted compounds, offering predictable reactivity in multi-step synthetic sequences.

Synthesis

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  770690-25-0
References
- Cole, Andrew G.; Bohnstedt, Adolph C.; Paradkar, Vidyadhar; Kingsbury, Celia; Quintero, Jorge G.; Park, Haengsoon; Lu, Yingchun; You, Ming; Neagu, Irina; Diller, David J.; Letourneau, Jeffrey J.; Shao, Yuefei; James, Ray A.; Riviello, Christopher M.; Ho, Koc-Kan; Lin, Tsung H.; Wang, Bojing; Appell, Kenneth C.; Sills, Matthew; Quadros, Elizabeth; Kimble, Earl F.; Ohlmeyer, Michael H.J.; Webb, Maria L. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 23 p. 6788 - 6792

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 35.25
LogP 2.1223
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Other aromatic heterocycles compounds

Key Words

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8-Chlorochroman-4-amine

CAS No. 770690-25-0

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