Lot numbers can be found on the outside label of a product:
6-Chlorochroman-4-amine
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CAS No. 765880-61-3
- Cat. No. CS-0005275
- Purity≥95%
- MDL No.MFCD07371530
*For research and further manufacturing use only, not for direct human use.
Structure of 765880-61-3
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General Information
- CAS No. 765880-61-3
- Cat. No. CS-0005275
- Purity ≥95%
- MDL No. MFCD07371530
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₁₀ClNO
- Molecular Weight 183.63
- Synonym(s) 6-Chloro-chroman-4-ylamine
- SMILES NC1CCOC2=CC=C(Cl)C=C12
Description
6-Chlorochroman-4-amine features a chlorine-substituted chroman scaffold with a primary amine at the 4-position, offering enhanced electron density and improved solubility in polar organic solvents. This bench-stable compound serves as a key intermediate in the synthesis of bioactive heterocycles and pharmaceutical candidates, particularly in kinase inhibitor development.
Application
6-Chlorochroman-4-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its chloro substituent offers a reliable handle for palladium-catalyzed cross-coupling, while the primary amine facilitates conjugation and derivatization. The chroman scaffold provides structural rigidity and metabolic stability, enhancing its utility in drug discovery programs targeting CNS and kinase pathways.
Synthesis
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Route1
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In-stock
37674-72-9 - ~%
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In-stock
765880-61-3
References
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Goffin, Eric; Lamoral-Theys, Delphine; Tajeddine, Nicolas; De Tullio, Pascal; Mondin, Ludivine; Lefranc, Florence; Gailly, Philippe; Rogister, Bernard; Kiss, Robert; Pirotte, Bernard European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 834 - 844
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Route2
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147592-12-9 - ~%
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In-stock
765880-61-3
References
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Goffin, Eric; Lamoral-Theys, Delphine; Tajeddine, Nicolas; De Tullio, Pascal; Mondin, Ludivine; Lefranc, Florence; Gailly, Philippe; Rogister, Bernard; Kiss, Robert; Pirotte, Bernard European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 834 - 844
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Route3
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In-stock
3284-79-5 - ~%
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In-stock
765880-61-3
References
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Goffin, Eric; Lamoral-Theys, Delphine; Tajeddine, Nicolas; De Tullio, Pascal; Mondin, Ludivine; Lefranc, Florence; Gailly, Philippe; Rogister, Bernard; Kiss, Robert; Pirotte, Bernard European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 834 - 844
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362+P364
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Quality Control
Computational Chemistry Data
- TPSA 35.25
- LogP 2.1223
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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