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CS-W001157 4
Total: USD 88.00

3-(4-Chlorophenoxy)propanoic acid

  • CAS No. 3284-79-5

  • Cat. No. CS-W015588
  • Purity≥98%
  • MDL No.MFCD00043504

*For research and further manufacturing use only, not for direct human use.

3-(4-Chlorophenoxy)propanoic acid|CS-W015588

Structure of 3284-79-5

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General Information

  • CAS No. 3284-79-5
  • Cat. No. CS-W015588
  • Purity ≥98%
  • MDL No. MFCD00043504
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉ClO₃
  • Molecular Weight 200.62
  • Synonym(s) 3-(P-CHLOROPHENOXY)PROPIONIC ACID
  • SMILES O=C(O)CCOC1=CC=C(Cl)C=C1

Description

3-(4-Chlorophenoxy)propanoic acid features a chlorinated phenoxy linkage paired with a carboxylic acid-bearing aliphatic chain, enabling direct integration into bioactive molecule scaffolds. This structure supports efficient coupling in synthetic pathways requiring polar, electron-deficient aryl components. The compound exhibits robust stability under standard bench conditions and facilitates straightforward derivatization for agrochemical or pharmaceutical applications.

Application

3-(4-Chlorophenoxy)propanoic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling the construction of bioactive heterocyclic scaffolds. Its well-established stability and compatibility with standard coupling protocols facilitate efficient amide and ester formation. The molecule’s ortho-substituted phenoxy functionality provides favorable lipophilicity and metabolic resistance, enhancing its utility in lead optimization campaigns.

Synthesis

  • Route1
    • null|null
      590-92-1
    • null|null
      106-48-9
    • ~23%
    • In-stock
      3-(4-Chlorophenoxy)propanoic acid|CS-W015588
      3284-79-5

    References

    • Goffin, Eric; Lamoral-Theys, Delphine; Tajeddine, Nicolas; De Tullio, Pascal; Mondin, Ludivine; Lefranc, Florence; Gailly, Philippe; Rogister, Bernard; Kiss, Robert; Pirotte, Bernard European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 834 - 844
  • Route2

    References

    • US2449991 , ;
  • Route3
    • 3-(4-Chlorophenoxy)propan-1-ol|CS-0582566
      18673-04-6
    • ~%
    • In-stock
      3-(4-Chlorophenoxy)propanoic acid|CS-W015588
      3284-79-5

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 1 p. 310 - 317

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   2.1935
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   4

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