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CS-W001157 4
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[(3-Bromocyclobutoxy)methyl]benzene

  • CAS No. 1443110-01-7

  • Cat. No. CS-0053054
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

[(3-Bromocyclobutoxy)methyl]benzene|CS-0053054

Structure of 1443110-01-7

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General Information

  • CAS No. 1443110-01-7
  • Cat. No. CS-0053054
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₃BrO
  • Molecular Weight 241.12
  • Synonym(s) {[(3-Bromocyclobutyl)oxy]methyl}benzene
  • SMILES BrC1CC(C1)OCC1=CC=CC=C1

Description

This brominated cyclobutyl ether integrates a reactive alkylating handle, enabling direct functionalization in cross-coupling and nucleophilic substitution processes. The benzyl-linked cyclobutane ring imparts rigidity and enhanced metabolic stability, while the terminal bromide facilitates efficient C–C bond formation under standard conditions.

Application

[(3-Bromocyclobutoxy)methyl]benzene serves as a versatile building block for the synthesis of functionalized cyclobutane derivatives, enabling efficient C–O bond formation in Suzuki-Miyaura and Stille coupling reactions. Its bromine substituent facilitates palladium-catalyzed cross-coupling with boronic acids and stannanes, while the benzyl-linked cyclobutoxy moiety offers enhanced stability and ease of purification. This compound functions as a key intermediate in constructing bioactive heterocyclic scaffolds and medicinal chemistry libraries.

Safety Information

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GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331-H341
Precautionary Statements : P233-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P405-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   3.1291
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   3

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