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CS-W001157 4
Total: USD 88.00

KSD 2405

  • CAS No. 620-24-6

  • Cat. No. CS-0008490
  • Purity≥98%
  • MDL No.MFCD00004643

*For research and further manufacturing use only, not for direct human use.

KSD 2405|CS-0008490

Structure of 620-24-6

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General Information

  • CAS No. 620-24-6
  • Cat. No. CS-0008490
  • Purity ≥98%
  • MDL No. MFCD00004643
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈O₂
  • Molecular Weight None
  • Synonym(s) None
  • SMILES OC1=CC(CO)=CC=C1

Description

KSD 2405 is a bench-stable, moisture-tolerant boronate ester featuring a sterically hindered aryl group that enables efficient cross-coupling under mild conditions. This reagent integrates seamlessly into synthetic workflows requiring selective C–C bond formation, offering high functional group compatibility and reliable performance in process-scale applications.

Application

KSD 2405 serves as a robust building block for constructing complex heterocyclic scaffolds, particularly in the synthesis of bioactive nitrogen-containing rings. Its well-defined reactivity enables efficient coupling with diverse electrophiles and nucleophiles under mild conditions, facilitating rapid access to functionalized intermediates. The compound exhibits excellent bench stability, ease of purification, and compatibility with common protecting group strategies, making it a practical choice for iterative synthetic campaigns in medicinal chemistry and process development.

Synthesis

  • Route1

    References

    • Zhou, Yuhan; Gao, Guchao; Li, Hui; Qu, Jingping Tetrahedron Letters, 2008 , vol. 49, # 20 p. 3260 - 3263
  • Route2
    • null|null
      134390-31-1
    • ~71%
    • In-stock
      KSD 2405|CS-0008490
      620-24-6

    References

    • Padwa, Albert; Bullock, William H.; Norman, Bryan H.; Perumattam, John Journal of Organic Chemistry, 1991 , vol. 56, # 13 p. 4252 - 4259
  • Route3

    References

    • Synlett, , vol. 23, # 5 p. 706 - 710

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.8845
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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