2-Chloro-N-ethylpyrimidin-4-amine

Name: 2-Chloro-N-ethylpyrimidin-4-amine
Brand: ChemScene
Availability: InStock
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CAS No. 86443-51-8
Cat. No. CS-0045872
Purity≥98%
MDL No.MFCD09055369

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-N-ethylpyrimidin-4-amine|CS-0045872

Structure of 86443-51-8

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General Information

CAS No. 86443-51-8
Cat. No. CS-0045872
Purity ≥98%
MDL No. MFCD09055369
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₈ClN₃
Molecular Weight 157.60
Synonym(s) N-(2-Chloropyrimidin-4-yl)-N-ethylamine
SMILES CCNC1=NC(Cl)=NC=C1

Description

2-Chloro-N-ethylpyrimidin-4-amine features a pyrimidine core bearing a chloro group at C2 and an ethylamino substituent at C4, enabling direct incorporation into heterocyclic scaffolds. This electron-deficient pyrimidine serves as a key intermediate in medicinal chemistry, particularly for kinase inhibitor development and nucleoside analog synthesis. The molecule exhibits enhanced solubility and stability under standard reaction conditions, facilitating efficient coupling processes.

Application

2-Chloro-N-ethylpyrimidin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. The chloro group facilitates nucleophilic substitution reactions, while the N-ethylamino functionality offers tunable basicity and solubility. This compound exhibits bench stability and compatibility with standard coupling protocols, making it well-suited for modular synthesis of kinase inhibitors and other bioactive heterocycles.

Synthesis

Route1
- In-stock
  
  1233026-31-7
- 75-04-7
- ~77%
- In-stock
  
  86443-51-8
References
- Synthesis (Germany), , vol. 45, # 13 art. no. SS-2013-C0253-OP, p. 1764 - 1784
Route2
- 3934-20-1
- 75-04-7
- ~44%
- In-stock
  
  86443-51-8
References
- Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 8 p. 2560 - 2563

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 37.81
LogP 1.5618
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2-Chloro-N-ethylpyrimidin-4-amine

CAS No. 86443-51-8

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