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CS-W001157 4
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tert-Butyl 4-(aminomethyl)-4-fluoropiperidine-1-carboxylate

  • CAS No. 620611-27-0

  • Cat. No. CS-W023003
  • Purity≥98%
  • MDL No.MFCD11847970

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(aminomethyl)-4-fluoropiperidine-1-carboxylate|CS-W023003

Structure of 620611-27-0

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General Information

  • CAS No. 620611-27-0
  • Cat. No. CS-W023003
  • Purity ≥98%
  • MDL No. MFCD11847970
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₁FN₂O₂
  • Molecular Weight 232.30
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CCC(F)(CN)CC1

Description

tert-Butyl 4-(aminomethyl)-4-fluoropiperidine-1-carboxylate delivers a fluorinated piperidine scaffold with a pendant primary amine, enabling direct functionalization in medicinal chemistry. The tert-butyl carbamate protects the amine during synthesis, offering stability and ease of handling under standard conditions. This building block integrates readily into bioactive molecules requiring constrained, electron-deficient heterocycles with tunable polarity.

Application

tert-Butyl 4-(aminomethyl)-4-fluoropiperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated piperidine scaffolds prevalent in bioactive molecules. The protected amine and fluorinated aliphatic center offer orthogonal reactivity, facilitating downstream functionalization via nucleophilic substitution or reductive amination. Its bench-stable nature and compatibility with standard purification methods make it ideal for multi-step synthesis and process-scale applications.

Synthesis

  • Route1
    • null|null
      1228765-02-3
    • ~68%
    • In-stock
      tert-Butyl 4-(aminomethyl)-4-fluoropiperidine-1-carboxylate|CS-W023003
      620611-27-0

    References

    • Verniest, Guido; Piron, Karel; Van Hende, Eva; Thuring, Jan Willem; MacDonald, Gregor; Deroose, Frederik; De Kimpe, Norbert Organic and Biomolecular Chemistry, 2010 , vol. 8, # 11 p. 2509 - 2512
  • Route2
    • null|null
      620611-28-1
    • ~%
    • In-stock
      tert-Butyl 4-(aminomethyl)-4-fluoropiperidine-1-carboxylate|CS-W023003
      620611-27-0

    References

    • EP1505067 A1, ; Page/Page column 369 ; EP 1505067 A1
  • Route3

    References

    • Verniest, Guido; Piron, Karel; Van Hende, Eva; Thuring, Jan Willem; MacDonald, Gregor; Deroose, Frederik; De Kimpe, Norbert Organic and Biomolecular Chemistry, 2010 , vol. 8, # 11 p. 2509 - 2512

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.56
  • LogP   1.6843
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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