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Structure of 39576-82-4
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2,4-Dichloro-6-methylquinazoline is a bench-stable heterocyclic scaffold featuring electron-deficient aromatic character and orthogonal reactivity. The chloro groups enable palladium-catalyzed cross-coupling, while the methyl substituent enhances solubility and modulates electronic properties. This compound serves as a core building block for kinase inhibitors and bioactive quinazoline derivatives in medicinal chemistry.
2,4-Dichloro-6-methylquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The dichloro substitution pattern provides orthogonal reactivity for sequential derivatization, while the methyl group enhances metabolic stability and modulates electronic properties. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for scalable synthesis of kinase inhibitors and other bioactive heterocycles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: