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CS-W001157 4
Total: USD 88.00

2-Chloro-2,2-difluoro-1-phenylethanone

  • CAS No. 384-67-8

  • Cat. No. CS-W015867
  • Purity≥95%
  • MDL No.MFCD00042123

*For research and further manufacturing use only, not for direct human use.

2-Chloro-2,2-difluoro-1-phenylethanone|CS-W015867

Structure of 384-67-8

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General Information

  • CAS No. 384-67-8
  • Cat. No. CS-W015867
  • Purity ≥95%
  • MDL No. MFCD00042123
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅ClF₂O
  • Molecular Weight None
  • Synonym(s) N-(2-fluorophenyl)-β-alanine
  • SMILES FC(F)(Cl)C(C1=CC=CC=C1)=O

Description

DBCO-NHCO-PEG5-acid is an analog of DBCO-Acid with a hydrophilic PEG spacer arm, which improves water solubility. This reagent is a non-activated building block with enhanced solubility in aqueous media and can thus be used to derivatize amine-containing molecule through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.

Synthesis

  • Route1
    • ((2,2-Difluoro-1-phenylvinyl)oxy)trimethylsilane|CS-1153207
      86340-78-5
    • ~86%
    • In-stock
      2-Chloro-2,2-difluoro-1-phenylethanone|CS-W015867
      384-67-8

    References

    • Zhang, Laijun; Zheng, Ji; Hu, Jinbo Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9845 - 9848
  • Route2
    • null|null
      71-43-2
    • ~%
    • In-stock
      2-Chloro-2,2-difluoro-1-phenylethanone|CS-W015867
      384-67-8

    References

    • Cohen; Wolosinski; Scheuer Journal of the American Chemical Society, 1949 , vol. 71, p. 3439
  • Route3
    • null|null
      2902-69-4
    • ~%
    • In-stock
      2-Chloro-2,2-difluoro-1-phenylethanone|CS-W015867
      384-67-8

    References

    • Simons; Herman Journal of the American Chemical Society, 1943 , vol. 65, p. 2064

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: 3334
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.7009
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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