2,4-Dichloro-5-methylquinazoline

Name: 2,4-Dichloro-5-methylquinazoline
Brand: ChemScene
Availability: InStock
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CAS No. 78052-20-7
Cat. No. CS-0312354
Purity≥98%
MDL No.MFCD11047029

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,4-Dichloro-5-methylquinazoline|CS-0312354

Structure of 78052-20-7

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General Information

CAS No. 78052-20-7
Cat. No. CS-0312354
Purity ≥98%
MDL No. MFCD11047029
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₆Cl₂N₂
Molecular Weight 213.06
Synonym(s) None
SMILES CC1=CC=CC2=NC(Cl)=NC(Cl)=C12

Description

2,4-Dichloro-5-methylquinazoline serves as a key heterocyclic scaffold in medicinal chemistry, featuring two chlorine substituents at electron-deficient positions and a methyl group at the 5-position. This combination enhances reactivity in nucleophilic substitution processes, enabling efficient coupling for pharmaceutical intermediates. The molecule exhibits good stability under standard bench conditions and facilitates rapid diversification in drug discovery campaigns.

Application

2,4-Dichloro-5-methylquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The dichloro substitution pattern provides orthogonal reactivity for sequential derivatization, while the methyl group enhances solubility and modulates electronic properties. Bench-stable and readily purified by column chromatography, it functions as a key scaffold for constructing kinase inhibitor libraries and other bioactive heterocycles.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 25.78
LogP 3.24502
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

Key Words

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2,4-Dichloro-5-methylquinazoline

CAS No. 78052-20-7

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