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Structure of 864291-30-5
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2,4-Dichloro-6-(trifluoromethyl)quinazoline is a bench-stable heterocyclic scaffold featuring electron-deficient aryl character, enabling efficient coupling in cross-coupling and nucleophilic substitution reactions. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the dichloro substitution pattern provides regioselective reactivity for functionalization in medicinal chemistry and materials science applications.
2,4-Dichloro-6-(trifluoromethyl)quinazoline serves as a versatile building block in medicinal chemistry, enabling the synthesis of kinase inhibitors and other bioactive heterocycles. Its reactive chlorines facilitate nucleophilic substitution under mild conditions, while the trifluoromethyl group enhances metabolic stability and lipophilicity. The compound exhibits good bench stability and compatibility with standard coupling protocols, making it well-suited for iterative synthetic campaigns in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: