2,4-Dichloro-7-(trifluoromethyl)quinazoline

Name: 2,4-Dichloro-7-(trifluoromethyl)quinazoline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 396-02-1
Cat. No. CS-0052155
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,4-Dichloro-7-(trifluoromethyl)quinazoline|CS-0052155

Structure of 396-02-1

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Description

2,4-Dichloro-7-(trifluoromethyl)quinazoline features a trifluoromethyl group that enhances metabolic stability and lipophilicity, while the dichloro substitution pattern supports targeted electrophilic functionalization. This quinazoline scaffold serves as a privileged core in kinase inhibitor design, enabling efficient integration into bioactive molecules under standard coupling conditions.

Application

2,4-Dichloro-7-(trifluoromethyl)quinazoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of kinase inhibitors and heterocyclic scaffolds. The dichloro substitution pattern facilitates selective nucleophilic aromatic substitution, while the trifluoromethyl group enhances metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with standard coupling reactions make it ideal for parallel synthesis campaigns and API development workflows.

General Information

CAS No. 396-02-1
Cat. No. CS-0052155
Purity ≥97%
MDL No. None
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₃Cl₂F₃N₂
Molecular Weight 267.03
Synonym(s) 2,4-Dichloro-7-(trifluoromethyl)
SMILES FC(F)(F)C1=CC2=C(C=C1)C(Cl)=NC(Cl)=N2

Computational Chemistry Data

TPSA 25.78
LogP 3.9554
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

Key Words

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2,4-Dichloro-7-(trifluoromethyl)quinazoline

CAS No. 396-02-1

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