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CS-W001157 4
Total: USD 88.00

2,4-Dichloroquinazoline

  • CAS No. 607-68-1

  • Cat. No. CS-D0819
  • Purity≥97%
  • MDL No.MFCD00091950

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloroquinazoline|CS-D0819

Structure of 607-68-1

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General Information

  • CAS No. 607-68-1
  • Cat. No. CS-D0819
  • Purity ≥97%
  • MDL No. MFCD00091950
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄Cl₂N₂
  • Molecular Weight 199.04
  • Synonym(s) QUINAZOLINE,2,4-DICHLORO-6,7-DIMETHOXY-; 2,4-Dichloroquinazoline
  • SMILES ClC1=NC(Cl)=NC2=CC=CC=C12

Description

2,4-Dichloroquinazoline is a bench-stable, electron-deficient heterocycle featuring two chlorine substituents at the 2- and 4-positions of the quinazoline core. This configuration enhances reactivity in nucleophilic substitution processes, enabling efficient coupling with amines, thiols, and other soft nucleophiles under mild conditions. The molecule integrates readily into bioactive scaffolds due to its planar structure and moderate lipophilicity, making it valuable for medicinal chemistry and chemical biology applications.

Application

2,4-Dichloroquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of quinazoline-based scaffolds. The dichloro substitution pattern facilitates regioselective palladium-catalyzed cross-coupling reactions and nucleophilic aromatic substitution, offering reliable access to functionalized derivatives. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for iterative synthesis workflows in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.9366
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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