Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

1-Fluoro-4-nitrobenzene

  • CAS No. 350-46-9

  • Cat. No. CS-W008789
  • Purity≥98%
  • MDL No.MFCD00007282

*For research and further manufacturing use only, not for direct human use.

1-Fluoro-4-nitrobenzene|CS-W008789

Structure of 350-46-9

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 350-46-9
  • Cat. No. CS-W008789
  • Purity ≥98%
  • MDL No. MFCD00007282
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄FNO₂
  • Molecular Weight None
  • Synonym(s) Para-fluoronitrobenzene; p-Fluoronitrobenzene; p-Nitrofluorobenzene; 1-Fluoro-4-nitrobenzene
  • SMILES O=[N+](C1=CC=C(F)C=C1)[O-]

Description

1-Fluoro-4-nitrobenzene features a para-substituted aromatic ring with complementary electron-withdrawing nitro and fluorine groups, enabling efficient nucleophilic aromatic substitution under mild conditions. This bench-stable compound integrates readily into synthetic sequences requiring selective C–X bond activation, particularly in the construction of bioactive heterocycles and functionalized aryl building blocks.

Application

1-Fluoro-4-nitrobenzene serves as a versatile arylating agent in nucleophilic aromatic substitution reactions, enabling efficient construction of biaryl and heterocyclic scaffolds. Its ortho-directing nitro group enhances reactivity while maintaining bench stability and compatibility with diverse nucleophiles, including amines, thiols, and carbanions. The compound functions reliably in standard synthetic workflows, facilitating the introduction of complex functional groups under mild conditions.

Synthesis

  • Route1

    References

    • Bl. Acad. Belg., vol. <5> 12, p. 824 Chem. Zentralbl., , vol. 98, # I p. 885 Chem. Zentralbl., , vol. 98, # II p. 1146
  • Route2

    References

    • Bulletin de la Classe des Sciences, Academie Royale de Belgique, , vol. <5> 7, p. 536 Chem. Zentralbl., , vol. 93, # I p. 22
  • Route3
    • null|null
      100-01-6
    • ~90%
    • In-stock
      1-Fluoro-4-nitrobenzene|CS-W008789
      350-46-9

    References

    • Laali, Kenneth K.; Gettwert, Volker J. Journal of Fluorine Chemistry, 2001 , vol. 107, # 1 p. 31 - 34

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H227-H302+H312-H331-H373-H412
Precautionary Statements : P210-P260-P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P403-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   43.14
  • LogP   1.7339
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 1-Fluoro-4-nitrobenzene sigma1-Fluoro-4-nitrobenzene manufacturer1-Fluoro-4-nitrobenzene price1-Fluoro-4-nitrobenzene structure1-Fluoro-4-nitrobenzene SDSbuy 1-Fluoro-4-nitrobenzene1-Fluoro-4-nitrobenzene supplier1-Fluoro-4-nitrobenzene uses1-Fluoro-4-nitrobenzene molecular weightprice of 1-Fluoro-4-nitrobenzene1-Fluoro-4-nitrobenzene chemical name formula of 1-Fluoro-4-nitrobenzene
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label