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CS-W001157 4
Total: USD 88.00

m-Fluoronitrobenzene

  • CAS No. 402-67-5

  • Cat. No. CS-W018306
  • Purity≥97%
  • MDL No.MFCD00007196

*For research and further manufacturing use only, not for direct human use.

m-Fluoronitrobenzene|CS-W018306

Structure of 402-67-5

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General Information

  • CAS No. 402-67-5
  • Cat. No. CS-W018306
  • Purity ≥97%
  • MDL No. MFCD00007196
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄FNO₂
  • Molecular Weight 141.10
  • Synonym(s) 1-Fluoro-3-nitrobenzene; 3-Fluoronitrobenzene; m-FNBZ
  • SMILES O=[N+](C1=CC(F)=CC=C1)[O-]

Description

1-Fluoro-3-nitrobenzene was used as an internal standard in the regiospecific silver-mediated fluorination of aryl silanes.

Application

1-Fluoro-3-nitrobenzene serves as a versatile bifunctional building block in synthetic organic chemistry, enabling directed ortho-metalation and transition-metal-catalyzed cross-coupling reactions. The fluorine and nitro groups exhibit complementary reactivity: the fluorine facilitates electrophilic substitution or nucleophilic aromatic substitution under mild conditions, while the nitro group acts as a strong electron-withdrawing director and can be readily reduced to an amine for further functionalization. Its bench stability and compatibility with standard purification methods make it a reliable intermediate in the synthesis of pharmaceuticals and agrochemicals.

Synthesis

  • Route1
    • null|null
      99-09-2
    • ~92%
    • In-stock
      m-Fluoronitrobenzene|CS-W018306
      402-67-5

    References

    • Laali, Kenneth K.; Gettwert, Volker J. Journal of Fluorine Chemistry, 2001 , vol. 107, # 1 p. 31 - 34
  • Route2
    • null|null
      99-65-0
    • ~94%
    • In-stock
      m-Fluoronitrobenzene|CS-W018306
      402-67-5

    References

    • Maggini, Michele; Passudetti, Margherita; Gonzales-Trueba, Guadalupe; Prato, Maurizio; Quintily, Ugo; Scorrano, Gianfranco Journal of Organic Chemistry, 1991 , vol. 56, # 22 p. 6406 - 6411
  • Route3
    • null|null
      121-51-7
    • ~6%
    • In-stock
      m-Fluoronitrobenzene|CS-W018306
      402-67-5
    • 3-Fluorobenzene-1-sulfonyl fluoride|CS-0719211
      1547-91-7

    References

    • Suzuki, Hiroshi; Yazawa, Naoto; Yoshida, Yasuo; Furusawa, Osamu; Kimura, Yoshikazu Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 7 p. 2010 - 2017

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅱ
Hazard Statements : H412-H301+H311+H331-H315-H319-H335-H351-H373
Precautionary Statements : P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P363-P403+P233-P405-P501-P305+P351+P338-P332+P317-P337+P317-P362+P364-P273

Quality Control

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Computational Chemistry Data

  • TPSA   43.14
  • LogP   1.7339
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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