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CS-W001157 4
Total: USD 88.00

1-(6-Fluoropyridin-3-yl)ethanone

  • CAS No. 84331-14-6

  • Cat. No. CS-W003402
  • Purity≥97%
  • MDL No.MFCD07375076

*For research and further manufacturing use only, not for direct human use.

1-(6-Fluoropyridin-3-yl)ethanone|CS-W003402

Structure of 84331-14-6

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General Information

  • CAS No. 84331-14-6
  • Cat. No. CS-W003402
  • Purity ≥97%
  • MDL No. MFCD07375076
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FNO
  • Molecular Weight 139.13
  • Synonym(s) Ethanone, 1-(6-fluoro-3-pyridinyl)- (9CI)
  • SMILES Fc1ccc(cn1)C(=O)C

Description

1-(6-Fluoropyridin-3-yl)ethanone features a fluorinated pyridine ring paired with a ketone-functionalized ethyl side chain, enabling direct integration into heterocyclic synthesis. The electron-deficient aromatic core enhances reactivity in nucleophilic substitution and transition metal-catalyzed coupling reactions. This bench-stable compound serves as a key building block for pharmaceutical intermediates and functional materials.

Application

1-(6-Fluoropyridin-3-yl)ethanone serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles via nucleophilic substitution or palladium-catalyzed coupling. The fluorinated pyridine moiety enhances metabolic stability and modulates electronic properties, while the acetyl group provides a handle for further functionalization. Bench-stable and compatible with standard purification techniques, it facilitates scalable synthesis of target molecules in drug discovery programs.

Synthesis

  • Route1
    • 6-Fluoro-n-methoxy-n-methylnicotinamide|CS-0874802
      774239-06-4
    • null|null
      75-16-1
    • ~68%
    • In-stock
      1-(6-Fluoropyridin-3-yl)ethanone|CS-W003402
      84331-14-6

    References

    • WO2006/82392 A1, ; Page/Page column 116 ; WO 2006/082392 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.4233
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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