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CS-W001157 4
Total: USD 88.00

2-Fluoropyridine-5-carbaldehyde

  • CAS No. 677728-92-6

  • Cat. No. CS-W004680
  • Purity≥98%
  • MDL No.MFCD08064049

*For research and further manufacturing use only, not for direct human use.

2-Fluoropyridine-5-carbaldehyde|CS-W004680

Structure of 677728-92-6

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General Information

  • CAS No. 677728-92-6
  • Cat. No. CS-W004680
  • Purity ≥98%
  • MDL No. MFCD08064049
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄FNO
  • Molecular Weight None
  • Synonym(s) 6-fluoropyridine-3-carbaldehyde
  • SMILES FC1=NC=C(C=C1)C=O

Description

2-Fluoropyridine-5-carbaldehyde features a fluorinated pyridine ring paired with an aldehyde group at the 5-position, enabling direct functionalization in heterocyclic synthesis. This electron-deficient scaffold integrates readily into pharmaceutical intermediates and ligand design, offering enhanced reactivity under standard conditions.

Application

2-Fluoropyridine-5-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyridine ring and aldehyde group. Its fluorinated heterocyclic core enhances metabolic stability and modulates electronic properties, while the aldehyde facilitates imine formation, reductive amination, and conjugate addition reactions. Bench-stable and compatible with standard purification methods, it functions effectively in coupling sequences, cyclizations, and late-stage diversification for API development.

Synthesis

  • Route1
    • In-stock
      5-Bromo-2-fluoropyridine|CS-D0938
      766-11-0
    • null|null
      68-12-2
    • ~%
    • In-stock
      2-Fluoropyridine-5-carbaldehyde|CS-W004680
      677728-92-6

    References

    • WO2009/89083 A1, ; Page/Page column 28; 30 ; WO 2009/089083 A1
  • Route2
    • In-stock
      5-Bromo-2-fluoropyridine|CS-D0938
      766-11-0
    • null|null
      107-31-3
    • ~%
    • In-stock
      2-Fluoropyridine-5-carbaldehyde|CS-W004680
      677728-92-6

    References

    • EP1595867 A1, ; Page/Page column 31 ; EP 1595867 A1
  • Route3

    References

    • Biochemistry, , vol. 49, # 49 p. 10421 - 10439

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.0332
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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