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(6-Fluoropyridin-3-yl)methanol

  • CAS No. 39891-05-9

  • Cat. No. CS-0044070
  • Purity≥96%
  • MDL No.MFCD03095186

*For research and further manufacturing use only, not for direct human use.

(6-Fluoropyridin-3-yl)methanol|CS-0044070

Structure of 39891-05-9

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General Information

  • CAS No. 39891-05-9
  • Cat. No. CS-0044070
  • Purity ≥96%
  • MDL No. MFCD03095186
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FNO
  • Molecular Weight 127.12
  • Synonym(s) 3-pyridinemethanol, 6-fluoro-
  • SMILES OCC1=CC=C(F)N=C1

Description

(6-Fluoropyridin-3-yl)methanol features a fluorinated pyridine ring with a pendant hydroxymethyl group, enabling direct functionalization at the 3-position. This bench-stable, moisture-tolerant scaffold integrates readily into synthetic routes requiring electron-deficient heterocyclic building blocks.

Application

(6-Fluoropyridin-3-yl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient incorporation of fluorinated pyridine motifs into target molecules. Its benzylic alcohol functionality facilitates straightforward derivatization via oxidation, etherification, or substitution reactions. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, making it well-suited for modular library synthesis and API development.

Synthesis

  • Route1

    References

    • French, Jarrod B.; Cen, Yana; Vrablik, Tracy L.; Xu, Ping; Allen, Eleanor; Hanna-Rose, Wendy; Sauve, Anthony A. Biochemistry, 2010 , vol. 49, # 49 p. 10421 - 10439
  • Route2

    References

    • MSD K.K. Patent: US2012/22078 A1, 2012 ; Location in patent: Page/Page column 10 ;
  • Route3

    References

    • Pesti; Huhn; Yin; Xing; Fortunak; Earl Journal of Organic Chemistry, 2000 , vol. 65, # 23 p. 7718 - 7722

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   0.713
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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