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CS-W001157 4
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5-Cyano-2-fluoropyridine

  • CAS No. 3939-12-6

  • Cat. No. CS-W003602
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Cyano-2-fluoropyridine|CS-W003602

Structure of 3939-12-6

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General Information

  • CAS No. 3939-12-6
  • Cat. No. CS-W003602
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃FN₂
  • Molecular Weight 122.10
  • Synonym(s) 6-fluoropyridine-3-carbonitrile
  • SMILES N#Cc1ccc(nc1)F

Description

5-Cyano-2-fluoropyridine features a strategically positioned cyano group and fluorine atom on the pyridine ring, enabling enhanced reactivity in cross-coupling processes. The electron-deficient aromatic core facilitates efficient nucleophilic substitution, while the bench-stable nature supports reliable handling under standard conditions.

Application

5-Cyano-2-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 3-position via nucleophilic substitution due to the ortho-fluoro activation. Its dual electron-withdrawing groups (cyano and fluoro) enhance reactivity in cross-coupling reactions and facilitate the construction of substituted pyridine scaffolds common in pharmaceuticals. The compound exhibits good bench stability and is compatible with standard purification methods.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 3439
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   36.68
  • LogP   1.09238
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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