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Structure of 3939-13-7
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3-Cyano-2-fluoropyridine features a strategically positioned cyano group and fluorine atom on the pyridine ring, enabling high reactivity in transition metal-catalyzed couplings. This electron-deficient heterocycle integrates readily into complex molecular architectures, particularly in medicinal chemistry scaffolds requiring polar, stable linkages.
3-Cyano-2-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 3-position via nucleophilic substitution due to the activating effect of the cyano group. The fluorine at the 2-position facilitates site-selective coupling reactions, particularly in palladium-catalyzed cross-couplings. Its bench-stable nature and compatibility with diverse reaction conditions make it a practical scaffold for constructing heterocyclic pharmacophores and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319
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Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501
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Lot numbers can be found on the outside label of a product: