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CS-W001157 4
Total: USD 88.00

(S)-Tetrahydrofuran-3-ol

  • CAS No. 86087-23-2

  • Cat. No. CS-D0600
  • Purity≥98%
  • MDL No.MFCD00064327

*For research and further manufacturing use only, not for direct human use.

(S)-Tetrahydrofuran-3-ol|CS-D0600

Structure of 86087-23-2

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General Information

  • CAS No. 86087-23-2
  • Cat. No. CS-D0600
  • Purity ≥98%
  • MDL No. MFCD00064327
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈O₂
  • Molecular Weight 88.11
  • Synonym(s) (+)-3-Hydroxytetrahydrofuran
  • SMILES O[C@@H]1COCC1

Description

(S)-Tetrahydrofuran-3-ol is a chiral cyclic alcohol featuring a hydroxyl group at the 3-position of the tetrahydrofuran ring. This stereochemically defined scaffold offers high functional group compatibility and serves as a valuable building block in asymmetric synthesis, particularly for constructing complex heterocyclic frameworks and bioactive molecules.

Application

(S)-Tetrahydrofuran-3-ol serves as a chiral building block for the synthesis of bioactive molecules and natural product analogs. Its well-defined stereochemistry and hydroxyl functionality enable reliable derivatization in asymmetric synthesis, including protection, oxidation, and coupling reactions. The compound exhibits good bench stability and facilitates efficient purification, making it valuable for medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • null|null
      42890-76-6
    • ~85%
    • In-stock
      (S)-Tetrahydrofuran-3-ol|CS-D0600
      86087-23-2

    References

    • Tandon, Vishnu K.; Leusen, Albert M. van; Wynberg, Hans Journal of Organic Chemistry, 1983 , vol. 48, # 16 p. 2767 - 2769
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    References

    • Takasago International Corporation Patent: US5780649 A1, 1998 ;
  • Route3

    References

    • Tetrahedron Asymmetry, , vol. 23, # 11-12 p. 898 - 903

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   -0.2324
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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