2,4,5-Trichloroquinazoline

Name: 2,4,5-Trichloroquinazoline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 134517-55-8
Cat. No. CS-W021495
Purity≥96%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 134517-55-8
Cat. No. CS-W021495
Purity ≥96%
MDL No. None
Storage -20°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₃Cl₃N₂
Molecular Weight 233.48
Synonym(s) 2,4-Dichloro-5-chloroquinazoline
SMILES ClC1=CC=CC2=NC(Cl)=NC(Cl)=C12

Description

2,4,5-Trichloroquinazoline features a highly electron-deficient quinazoline core with three strategically positioned chlorine substituents. This configuration enhances reactivity in nucleophilic substitution processes and provides stability under standard bench conditions. The molecule serves as a key scaffold for synthesizing bioactive heterocycles in medicinal chemistry and materials science applications.

Application

2,4,5-Trichloroquinazoline serves as a versatile building block in medicinal chemistry, enabling direct functionalization at multiple positions due to its electron-deficient heterocyclic core. The trichloro substitution pattern facilitates nucleophilic aromatic substitution (SNAr) under mild conditions, allowing efficient introduction of diverse amine and thiol derivatives. Its bench-stable nature and compatibility with common reaction protocols make it a practical choice for synthesizing kinase inhibitor scaffolds and other bioactive heterocycles.

Synthesis

Route1
- In-stock
  
  78754-81-1
- ~%
- In-stock
  
  134517-55-8
References
- US5688803 A1, ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 25.78
LogP 3.59
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

Key Words

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2,4,5-Trichloroquinazoline

CAS No. 134517-55-8

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