4-Bromo-3,5-difluorobenzaldehyde

Name: 4-Bromo-3,5-difluorobenzaldehyde
Brand: ChemScene
Availability: InStock
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CAS No. 135564-22-6
Cat. No. CS-0067534
Purity≥98%
MDL No.MFCD16659085

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Bromo-3,5-difluorobenzaldehyde|CS-0067534

Structure of 135564-22-6

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General Information

CAS No. 135564-22-6
Cat. No. CS-0067534
Purity ≥98%
MDL No. MFCD16659085
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₃BrF₂O
Molecular Weight 221.00
Synonym(s) None
SMILES O=CC1=CC(F)=C(Br)C(F)=C1

Description

4-Bromo-3,5-difluorobenzaldehyde features a trifunctional aromatic core with complementary electronic and steric properties. The aldehyde group enables direct coupling in cross-coupling and condensation reactions. Electron-withdrawing bromo and difluoro substituents enhance reactivity in palladium-catalyzed transformations while maintaining stability under standard bench conditions.

Application

4-Bromo-3,5-difluorobenzaldehyde serves as a versatile building block in medicinal chemistry and materials science, enabling efficient construction of complex heterocycles and functionalized aryl scaffolds. Its orthogonal reactivity profile—combining electrophilic bromine and electron-withdrawing fluorine substituents—facilitates palladium-catalyzed cross-coupling and nucleophilic addition reactions with high chemoselectivity. The aldehyde functionality allows for facile derivatization via imine formation, reductive amination, or Grignard additions, while the compound exhibits excellent bench stability and ease of purification, making it well-suited for scalable synthesis and process development workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 17.07
LogP 2.5398
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Aldehyde

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-Bromo-3,5-difluorobenzaldehyde

CAS No. 135564-22-6

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