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CS-W001157 4
Total: USD 88.00

2,4-Dichloropyrimidine-5-carboxylic acid amide

  • CAS No. 1240390-28-6

  • Cat. No. CS-W006700
  • Molecule weight192.00
  • Purity≥96%
  • MDL No.MFCD16658133

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloropyrimidine-5-carboxylic acid amide|CS-W006700

Structure of 1240390-28-6

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General Information

  • CAS No. 1240390-28-6
  • Cat. No. CS-W006700
  • Purity ≥96%
  • MDL No. MFCD16658133
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃Cl₂N₃O
  • Molecular Weight 192.00
  • Synonym(s) 2,4-Dichloropyrimidine-5-carboxamide
  • SMILES O=C(N)C1=CN=C(N=C1Cl)Cl

Description

This amide derivative features a pyrimidine core functionalized with dichloro substituents at the 2- and 4-positions and a carboxylic acid amide group at the 5-position, providing enhanced stability and synthetic versatility for use in pharmaceutical intermediates and bioactive molecule development.

Application

2,4-Dichloropyrimidine-5-carboxylic acid amide serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its dual chloro groups facilitate nucleophilic substitution reactions, while the carboxamide functionality offers compatibility with standard coupling protocols. The compound exhibits bench stability and ease of purification, supporting its use in multi-step synthesis workflows targeting bioactive heterocycles.

Synthesis

  • Route1
    • null|null
      2972-52-3
    • ~90%
    • In-stock
      2,4-Dichloropyrimidine-5-carboxylic acid amide|CS-W006700
      1240390-28-6

    References

    • Singh, Rajinder; Tso, Kin; Zhang, Jing; Duncton, Matthew; Alvarez, Salvador; Kolluri, Rao; Ramphal, John; Holland, Sacha Patent: US2011/130415 A1, 2011 ; Location in patent: Page/Page column 41 ;
  • Route2

    References

    • WO2010/129802 A1, ; Page/Page column 125 ; WO 2010/129802 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   68.87
  • LogP   0.8823
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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