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CS-W001157 4
Total: USD 88.00

CYP2E1-IN-1

  • CAS No. 38205-55-9

  • Cat. No. CS-0103333
  • Purity≥95%
  • MDL No.MFCD09029046

*For research and further manufacturing use only, not for direct human use.

CYP2E1-IN-1|CS-0103333

Structure of 38205-55-9

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General Information

  • CAS No. 38205-55-9
  • Cat. No. CS-0103333
  • Purity ≥95%
  • MDL No. MFCD09029046
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NOS
  • Molecular Weight 141.19
  • Synonym(s) None
  • SMILES CC(C1=C(N=CS1)C)=O

Description

CYP2E1-IN-1 is a potent, selective inhibitor of cytochrome P450 2E1, designed for research applications in metabolic pathway studies. This compound exhibits high affinity for the enzyme’s active site, enabling precise modulation of CYP2E1-dependent reactions under physiological conditions. Its stability and solubility support reliable use in cell-based assays and in vitro profiling.

Application

CYP2E1-IN-1 is a selective inhibitor of cytochrome P450 2E1, serving as a valuable tool compound for studying metabolic pathways and oxidative stress in toxicology and drug metabolism research. It exhibits high potency and specificity in vitro, enabling precise modulation of CYP2E1 activity without significant off-target effects. Its stability and solubility support reliable use in cellular assays and preclinical models, facilitating investigation into liver toxicity, ethanol metabolism, and the role of reactive oxygen species in disease progression.

Synthesis

  • Route1
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      115-08-2
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      1694-29-7
    • ~%
    • In-stock
      CYP2E1-IN-1|CS-0103333
      38205-55-9

    References

    • Sych,E.D.; Smaznaya-Jl'ina,E.D. J. Gen. Chem. USSR (Engl. Transl.), 1962 , vol. 32, p. 984 - 990,970 - 975
  • Route2
    • In-stock
      1-(2-Amino-4-methylthiazol-5-yl)ethanone|CS-W017739
      30748-47-1
    • null|null
      110-46-3
    • ~%
    • In-stock
      CYP2E1-IN-1|CS-0103333
      38205-55-9

    References

    • Fujisawa Pharmaceutical Co., Ltd. Patent: US4649146 A1, 1987 ;
  • Route3
    • null|null
      123-54-6
    • ~%
    • In-stock
      CYP2E1-IN-1|CS-0103333
      38205-55-9

    References

    • Buchman; Richardson Journal of the American Chemical Society, 1945 , vol. 67, p. 395,399

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.65412
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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