Lot numbers can be found on the outside label of a product:
Amino-4-methylthiazole
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CAS No. 1603-91-4
- Cat. No. CS-W009130
- Purity≥95%
- MDL No.MFCD00005329
*For research and further manufacturing use only, not for direct human use.
Structure of 1603-91-4
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General Information
- CAS No. 1603-91-4
- Cat. No. CS-W009130
- Purity ≥95%
- MDL No. MFCD00005329
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₄H₆N₂S
- Molecular Weight 114.17
- Synonym(s) Thiazole, 2-amino-4-methyl- (6CI,7CI,8CI); 2-Amino-4-methyl-1,3-thiazole; 4-methylthiazol-2-ylamine
- SMILES NC1=NC(C)=CS1
Description
Amino-4-methylthiazole features a nitrogen-rich heterocyclic core that integrates readily into bioactive scaffolds. The amino group enables direct functionalization, while the methyl substituent enhances solubility and metabolic stability. This compound serves as a key building block in medicinal chemistry, particularly for kinase inhibitors and antimicrobial agents.
Application
Amino-4-methylthiazole serves as a versatile building block in medicinal chemistry, enabling the construction of thiazole-based heterocycles prevalent in bioactive molecules. Its amino and methyl functionalities offer orthogonal reactivity for derivatization, while the core thiazole ring provides metabolic stability and favorable pharmacokinetic properties. The compound exhibits good bench stability and is readily incorporated into standard coupling and cyclization protocols, facilitating efficient synthesis of advanced intermediates for drug discovery applications.
Synthesis
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Route1
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17356-08-0 -
78-95-5
- ~73%
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In-stock
1603-91-4
References
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SPHAERA PHARMA PVT. LTD; DUGAR, Sundeep; MAHAJAN, Dinesh; DEOKAR, Rhushikesh, Chandraban; HOLLINGER, Frank, Peter; KAPOOR, Kamal, Kishore Patent: WO2012/101654 A2, 2012 ; Location in patent: Page/Page column 60 ; WO 2012/101654 A2
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Route2
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17356-08-0
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67-64-1
- ~72%
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In-stock
1603-91-4
References
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Huang, Guoli; Sun, Hongsheng; Qiu, Xiaojie; Jin, Can; Lin, Chen; Shen, Yingzhong; Jiang, Juli; Wang, Leyong Organic Letters, 2011 , vol. 13, # 19 p. 5224 - 5227
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Route3
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333-20-0
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78-95-5
- ~82%
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In-stock
1603-91-4
References
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Kodomari, Mitsuo; Aoyama, Tadashi; Suzuki, Yoshitada Tetrahedron Letters, 2002 , vol. 43, # 9 p. 1717 - 1720
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 38.91
- LogP 1.03372
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 0
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