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CS-W001157 4
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tert-Butyl (4-methylthiazol-2-yl)carbamate

  • CAS No. 848472-44-6

  • Cat. No. CS-0119829
  • Molecule weight214.28
  • Purity≥97%
  • MDL No.MFCD11501911

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (4-methylthiazol-2-yl)carbamate|CS-0119829

Structure of 848472-44-6

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General Information

  • CAS No. 848472-44-6
  • Cat. No. CS-0119829
  • Purity ≥97%
  • MDL No. MFCD11501911
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₄N₂O₂S
  • Molecular Weight 214.28
  • Synonym(s) tert-butyl N-(4-methyl-1,3-thiazol-2-yl)carbamate
  • SMILES O=C(OC(C)(C)C)NC1=NC(C)=CS1

Description

tert-Butyl (4-methylthiazol-2-yl)carbamate features a bench-stable, moisture-tolerant carbamate protecting group that selectively masks primary amines in heterocyclic systems. The electron-rich thiazole core enhances reactivity in cross-coupling and functionalization workflows, enabling efficient incorporation into complex molecular architectures under mild conditions.

Application

tert-Butyl (4-methylthiazol-2-yl)carbamate serves as a stable, bench-friendly building block for thiazole-based scaffolds in medicinal chemistry. The carbamate group enables orthogonal protection of nitrogen, facilitating selective deprotection under mild acidic conditions. It readily participates in palladium-catalyzed cross-coupling reactions and functions as a key intermediate in the synthesis of heterocyclic APIs and kinase inhibitors. Its stability, ease of purification, and compatibility with diverse functional groups support scalable, high-yield transformations.

Synthesis

  • Route1
    • Amino-4-methylthiazole Mirabegron  Impurity|CS-0229183
      1603-91-4
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • ~87%
    • In-stock
      tert-Butyl (4-methylthiazol-2-yl)carbamate|CS-0119829
      848472-44-6

    References

    • NORTHWESTERN UNIVERSITY Patent: WO2008/42353 A1, 2008 ; Location in patent: Page/Page column 29 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.22
  • LogP   2.79852
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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