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CS-W001157 4
Total: USD 88.00

3-Chloro-4-fluorobenzaldehyde

  • CAS No. 34328-61-5

  • Cat. No. CS-W017953
  • Purity≥97%
  • MDL No.MFCD00011735

*For research and further manufacturing use only, not for direct human use.

3-Chloro-4-fluorobenzaldehyde|CS-W017953

Structure of 34328-61-5

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General Information

  • CAS No. 34328-61-5
  • Cat. No. CS-W017953
  • Purity ≥97%
  • MDL No. MFCD00011735
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄ClFO
  • Molecular Weight 158.56
  • Synonym(s) 9H-Fluorene, 2-fluoro-; 3-Chloro-4-fluorobenzaldehyde
  • SMILES O=CC1=CC=C(F)C(Cl)=C1

Description

3-Chloro-4-fluorobenzaldehyde features a strategically positioned aldehyde group flanked by chlorine and fluorine substituents, delivering enhanced electrophilicity and metabolic stability. This electron-deficient aromatic scaffold integrates readily into pharmaceutical intermediates and functional materials, offering predictable reactivity under standard conditions.

Application

3-Chloro-4-fluorobenzaldehyde serves as a valuable building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of fluorinated aromatic scaffolds. Its orthogonal halogen functionality facilitates palladium-catalyzed cross-coupling reactions, while the aldehyde group supports nucleophilic additions and imine formation. Bench-stable and readily purified by distillation, it offers predictable reactivity in multi-step syntheses.

Synthesis

  • Route1
    • 3,4-Dichlorobenzaldehyde Ixazomib  Impurity|CS-0228770
      6287-38-3
    • ~65%
    • In-stock
      3-Chloro-4-fluorobenzaldehyde|CS-W017953
      34328-61-5

    References

    • Ihara Chemical Industry Co., Ltd. Patent: US4845304 A1, 1989 ;
  • Route2

    References

    • Molander, Gary A.; Cavalcanti, Livia N. Journal of Organic Chemistry, 2011 , vol. 76, # 17 p. 7195 - 7203
  • Route3
    • 4-Fluoro-3-chloroaniline Gefitinib Impurity|CS-0229026
      367-21-5
    • null|null
      75-17-2
    • ~%
    • In-stock
      3-Chloro-4-fluorobenzaldehyde|CS-W017953
      34328-61-5

    References

    • Journal of Medicinal Chemistry, , vol. 14, p. 862 - 866

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.2916
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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