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CS-W001157 4
Total: USD 88.00

4-Fluoro-3-chloroaniline Gefitinib Impurity

  • CAS No. 367-21-5

  • Cat. No. CS-0229026
  • Purity≥98%
  • MDL No.MFCD00007767

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-3-chloroaniline Gefitinib Impurity|CS-0229026

Structure of 367-21-5

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General Information

  • CAS No. 367-21-5
  • Cat. No. CS-0229026
  • Purity ≥98%
  • MDL No. MFCD00007767
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅ClFN
  • Molecular Weight 145.56
  • Synonym(s) None
  • SMILES NC1=CC=C(F)C(Cl)=C1

Synthesis

  • Route1
    • 2-Chloro-1-fluoro-4-nitrobenzene Afatinib Impurity|CS-0167290
      350-30-1
    • ~99%
    • 4-Fluoro-3-chloroaniline Gefitinib Impurity|CS-0229026
      367-21-5

    References

    • Fan, Guang-Yin; Zhang, Lei; Fu, Hai-Yan; Yuan, Mao-Lin; Li, Rui-Xiang; Chen, Hua; Li, Xian-Jun Catalysis Communications, 2010 , vol. 11, # 5 p. 451 - 455
  • Route2

    References

    • Recueil des Travaux Chimiques des Pays-Bas, , vol. 51, p. 98,109
  • Route3
    • null|null
      121-73-3
    • ~34%
    • 4-Fluoro-3-chloroaniline Gefitinib Impurity|CS-0229026
      367-21-5
    • null|null
      108-42-9

    References

    • Tordeux, Marc; Wakselman, Claude Journal of Fluorine Chemistry, 1995 , vol. 74, # 2 p. 251 - 254

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301+H311+H331-H373
Precautionary Statements : P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.0613
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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