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CS-W001157 4
Total: USD 88.00

tert-Butyl (4-(bromomethyl)thiazol-2-yl)carbamate

  • CAS No. 1001419-35-7

  • Cat. No. CS-0696353
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (4-(bromomethyl)thiazol-2-yl)carbamate|CS-0696353

Structure of 1001419-35-7

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General Information

  • CAS No. 1001419-35-7
  • Cat. No. CS-0696353
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₃BrN₂O₂S
  • Molecular Weight 293.18
  • Synonym(s) None
  • SMILES CC(C)(C)OC(=O)NC1=NC(CBr)=CS1

Description

tert-Butyl (4-(bromomethyl)thiazol-2-yl)carbamate delivers a bromomethyl-functionalized thiazole scaffold with a robust carbamate protecting group. This reagent integrates readily into synthetic sequences, enabling direct substitution at the thiazole C4 position. The pendant bromide serves as a high-affinity electrophile for nucleophilic displacement reactions, facilitating rapid access to complex heterocyclic architectures under mild conditions.

Application

tert-Butyl (4-(bromomethyl)thiazol-2-yl)carbamate serves as a versatile building block for thiazole-based scaffolds, enabling efficient late-stage functionalization via SN2 displacement. The bromomethyl group facilitates reliable coupling with nucleophiles, while the tert-butyl carbamate provides orthogonal protection and excellent bench stability. Its compatibility with standard cross-coupling protocols and ease of deprotection make it ideal for medicinal chemistry campaigns targeting heterocyclic APIs.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P264-P270-P271-P280-P304+P340-P330-P331-P363-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.22
  • LogP   3.385
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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