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CS-W001157 4
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tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate

  • CAS No. 494769-44-7

  • Cat. No. CS-W019385
  • Purity≥97%
  • MDL No.MFCD08275703

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate|CS-W019385

Structure of 494769-44-7

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General Information

  • CAS No. 494769-44-7
  • Cat. No. CS-W019385
  • Purity ≥97%
  • MDL No. MFCD08275703
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₄N₂O₃S
  • Molecular Weight 230.28
  • Synonym(s) tert-Butyl [4-(hydroxymethyl)-1,3-thiazol-2-yl]carbamate
  • SMILES OCC1=CSC(NC(OC(C)(C)C)=O)=N1

Description

tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate features a thiazole scaffold with a pendant hydroxymethyl group and a bench-stable carbamate protecting group. This combination enables selective derivatization in synthetic routes to bioactive heterocycles, particularly in medicinal chemistry applications requiring orthogonal functionalization.

Application

tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate serves as a versatile building block in medicinal chemistry, enabling straightforward access to thiazole-based scaffolds. The hydroxymethyl group facilitates selective oxidation to aldehyde or carboxylic acid, while the Boc-protected amine supports sequential functionalization. Its bench-stable nature and compatibility with standard coupling reactions make it ideal for iterative synthesis of complex heterocycles and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   71.45
  • LogP   1.9824
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   2

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