Lot numbers can be found on the outside label of a product:
1-(2,4-Dimethylthiazol-5-yl)ethan-1-one
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CAS No. 38205-60-6
- Cat. No. CS-0097780
- Purity≥98%
- MDL No.MFCD00005331
*For research and further manufacturing use only, not for direct human use.
Structure of 38205-60-6
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General Information
- CAS No. 38205-60-6
- Cat. No. CS-0097780
- Purity ≥98%
- MDL No. MFCD00005331
- Storage 4°C, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₉NOS
- Molecular Weight 155.22
- Synonym(s) 5-Acetyl-2,4-dimethylthiazole; 1-(2,4-Dimethylthiazol-5-yl)ethan-1-one
- SMILES CC(C1=C(C)N=C(C)S1)=O
Description
1-(2,4-Dimethylthiazol-5-yl)ethan-1-one features a sterically hindered thiazole core with methyl substituents at the 2- and 4-positions, enhancing stability and solubility in organic media. This electron-deficient acyl moiety integrates readily into heterocyclic synthesis, serving as a key building block for bioactive molecule construction under standard conditions.
Application
1-(2,4-Dimethylthiazol-5-yl)ethan-1-one serves as a versatile building block in medicinal chemistry, enabling efficient construction of thiazole-containing scaffolds. Its ketone functionality facilitates nucleophilic addition and condensation reactions, while the electron-rich thiazole ring enhances reactivity in cross-coupling and cyclization processes. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses requiring functional group tolerance and structural precision.
Synthesis
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Route1
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40236-03-1 - ~78%
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In-stock
38205-60-6
References
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Hangarge; Mane; Chavan; Shingare Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 6 p. 1302 - 1304
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Route2
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7660-21-1 -
In-stock
62-55-5 - ~%
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In-stock
38205-60-6
References
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Dr. Karl Thomas GmbH Patent: US4886814 A1, 1989 ;
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Route3
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In-stock
62-55-5
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1694-29-7
- ~%
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In-stock
38205-60-6
References
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Wang, Shudong; Midgley, Carol A.; Scaerou, Frederic; Grabarek, Joanna B.; Griffiths, Gary; Jackson, Wayne; Kontopidis, George; McClue, Steven J.; McInnes, Campbell; Meades, Christopher; Mezna, Mokdad; Plater, Andy; Stuart, Iain; Thomas, Mark P.; Wood, Gavin; Clarke, Rosemary G.; Blake, David G.; Zheleva, Daniella I.; Lane, David P.; Jackson, Robert C.; Glover, David M.; Fischer, Peter M. Journal of Medicinal Chemistry, 2010 , vol. 53, # 11 p. 4367 - 4378
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07,GHS08
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Signal Word : Danger
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H334-H335
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Precautionary Statements : P261-P264-P271-P280-P284-P302+P352-P304+P340-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 29.96
- LogP 1.96254
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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