1-Boc-3-methylazetidine-3-carboxylic acid

Name: 1-Boc-3-methylazetidine-3-carboxylic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 887591-62-0
Cat. No. CS-0028255
Purity≥97%
MDL No.MFCD12406581

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-Boc-3-methylazetidine-3-carboxylic acid|CS-0028255

Structure of 887591-62-0

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 887591-62-0
Cat. No. CS-0028255
Purity ≥97%
MDL No. MFCD12406581
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₇NO₄
Molecular Weight 215.25
Synonym(s) 1-(tert-Butoxycarbonyl)-3-methylazetidine-3-carboxylic acid
SMILES CC(C)(C)OC(N1CC(C(O)=O)(C)C1)=O

Description

1-Boc-3-methylazetidine-3-carboxylic acid features a sterically constrained azetidine core with a methyl group at the 3-position, enhancing metabolic stability. The Boc-protected carboxylic acid moiety enables facile deprotection under mild acidic conditions, allowing direct integration into peptide sequences or conjugation workflows. This bench-stable reagent supports efficient access to bioactive heterocycles in medicinal chemistry and fragment-based drug discovery.

Application

1-Boc-3-methylazetidine-3-carboxylic acid serves as a stable, bench-ready building block for the synthesis of azetidine-containing pharmaceuticals and bioactive molecules. The Boc group provides excellent protection of the carboxylic acid while maintaining compatibility with standard peptide coupling conditions. The tertiary α-carbon enables direct functionalization and facilitates incorporation into diverse heterocyclic scaffolds, including those found in kinase inhibitors and CNS-targeted therapeutics.

Synthesis

Route1
- In-stock
  
  142253-55-2
- 18107-18-1
- ~99%
- In-stock
  
  887591-62-0
References
- ASTRAZENECA AB Patent: WO2006/73361 A1, 2006 ; Location in patent: Page/Page column 171 ; WO 2006/073361 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 66.84
LogP 1.328
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Key Words

887591-62-0 sigma887591-62-0 manufacturer887591-62-0 price887591-62-0 structure887591-62-0 SDSbuy 887591-62-0887591-62-0 supplier887591-62-0 uses887591-62-0 molecular weightprice of 887591-62-0887591-62-0 chemical name formula of 887591-62-0

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

1-Boc-3-methylazetidine-3-carboxylic acid

CAS No. 887591-62-0

Recommended Products