tert-Butyl 3-(hydroxymethyl)-3-methylazetidine-1-carboxylate

Name: tert-Butyl 3-(hydroxymethyl)-3-methylazetidine-1-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 1363382-91-5
Cat. No. CS-0036896
Purity≥98%
MDL No.None

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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tert-Butyl 3-(hydroxymethyl)-3-methylazetidine-1-carboxylate|CS-0036896

Structure of 1363382-91-5

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General Information

CAS No. 1363382-91-5
Cat. No. CS-0036896
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₉NO₃
Molecular Weight 201.26
Synonym(s) 1-Boc-3-(hydroxyMethyl)-3-Methylazetidine
SMILES CC(C)(C)OC(=O)N1CC(C)(C1)CO

Description

tert-Butyl 3-(hydroxymethyl)-3-methylazetidine-1-carboxylate delivers a strained azetidine scaffold bearing a pendant hydroxymethyl group, enabling direct functionalization at the C3 position. This bench-stable, moisture-tolerant building block integrates readily into complex molecular architectures.

Application

tert-Butyl 3-(hydroxymethyl)-3-methylazetidine-1-carboxylate serves as a versatile building block for the synthesis of bioactive azetidine-containing scaffolds. The pendant hydroxymethyl group enables straightforward oxidation to aldehyde or carboxylic acid, facilitating downstream derivatization. Its tert-butyl carbamate protection offers excellent bench stability and compatibility with standard coupling reactions, while the strained azetidine core provides defined stereochemical control in medicinal chemistry applications.

Synthesis

Route1
- 898228-37-0
- ~%
- In-stock
  
  1363382-91-5
References
- BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ECKHARDT, Matthias; FRATTINI, Sara; HAMPRECHT, Dieter; HIMMELSBACH, Frank; LANGKOPF, Elke; LINGARD, Iain; PETERS, Stefan; WAGNER, Holger Patent: WO2013/144097 A1, 2013 ; Location in patent: Page/Page column 100 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 49.77
LogP 1.2357
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Key Words

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tert-Butyl 3-(hydroxymethyl)-3-methylazetidine-1-carboxylate

CAS No. 1363382-91-5

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