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CS-W001157 4
Total: USD 88.00

PhDave-Phos

  • CAS No. 240417-00-9

  • Cat. No. CS-W009748
  • Purity≥97%
  • MDL No.MFCD03094578

*For research and further manufacturing use only, not for direct human use.

PhDave-Phos|CS-W009748

Structure of 240417-00-9

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General Information

  • CAS No. 240417-00-9
  • Cat. No. CS-W009748
  • Purity ≥97%
  • MDL No. MFCD03094578
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₆H₂₄NP
  • Molecular Weight 381.45
  • Synonym(s) 2'-(Diphenylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; 2-Diphenylphosphino-2'-dimethylaminobiphenyl
  • SMILES CN(C)C(C=CC=C1)=C1C2=C(P(C3=CC=CC=C3)C4=CC=CC=C4)C=CC=C2

Application

PhDave-Phos serves as a highly effective, bench-stable ligand for palladium-catalyzed cross-coupling reactions. Its sterically hindered, electron-rich diphosphine structure enables efficient coupling of challenging substrates—particularly aryl chlorides and heteroaryl halides—under mild conditions. The ligand facilitates high yields and selectivity in Suzuki-Miyaura, Negishi, and Stille reactions, with excellent functional group tolerance and ease of purification. Its robust performance in both academic and industrial-scale applications underscores its value as a reliable tool for C–C bond formation.

Synthesis

  • Route1
    • null|null
      119326-02-2
    • null|null
      15475-27-1
    • ~47%
    • In-stock
      PhDave-Phos|CS-W009748
      240417-00-9

    References

    • Korte, Nicholas J.; Stepanova, Valeria A.; Smoliakova, Irina P. Journal of Organometallic Chemistry, 2013 , vol. 745-746, p. 356 - 362
  • Route2
    • null|null
      712350-51-1
    • ~96%
    • In-stock
      PhDave-Phos|CS-W009748
      240417-00-9

    References

    • Busacca, Carl A.; Raju, Ravinder; Grinberg, Nelu; Haddad, Nizar; James-Jones, Paul; Lee, Heewon; Lorenz, Jon C.; Saha, Anjan; Senanayake, Chris H. Journal of Organic Chemistry, 2008 , vol. 73, # 4 p. 1524 - 1531
  • Route3
    • null|null
      119326-02-2
    • null|null
      15475-27-1
    • ~47%
    • null|null
      6590-81-4
    • In-stock
      PhDave-Phos|CS-W009748
      240417-00-9

    References

    • Journal of Organometallic Chemistry, , vol. 745-746, p. 356 - 362

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   3.24
  • LogP   5.1778
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   5

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