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CS-W001157 4
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Tri-2-furanylphosphine

  • CAS No. 5518-52-5

  • Cat. No. CS-D1394
  • Purity≥97%
  • MDL No.MFCD00151857

*For research and further manufacturing use only, not for direct human use.

Tri-2-furanylphosphine|CS-D1394

Structure of 5518-52-5

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General Information

  • CAS No. 5518-52-5
  • Cat. No. CS-D1394
  • Purity ≥97%
  • MDL No. MFCD00151857
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₉O₃P
  • Molecular Weight 232.17
  • Synonym(s) Tris-furan-2-yl-phosphine
  • SMILES P(C1=CC=CO1)(C2=CC=CO2)C3=CC=CO3

Description

Tri-2-furanylphosphine features three 2-furyl groups attached to a central phosphorus atom, delivering high electron density and enhanced nucleophilicity. This sterically accessible ligand integrates readily into palladium-catalyzed cross-coupling reactions, offering improved reactivity under mild conditions. The furan rings contribute stability and solubility in polar organic solvents, enabling efficient coordination in transition metal complexes.

Application

Tri-2-furanylphosphine serves as a versatile, bench-stable ligand in transition metal catalysis, enabling efficient cross-coupling reactions under mild conditions. Its electron-rich furan rings enhance palladium and nickel catalyst activity while offering good functional group tolerance. The triarylphosphine scaffold facilitates purification and supports scalable synthesis of complex heterocyclic architectures common in pharmaceutical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.42
  • LogP   2.2238
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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