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CS-W001157 4
Total: USD 88.00

Tri-m-tolylphosphine

  • CAS No. 6224-63-1

  • Cat. No. CS-W012100
  • Purity≥97%
  • MDL No.MFCD00008532

*For research and further manufacturing use only, not for direct human use.

Tri-m-tolylphosphine|CS-W012100

Structure of 6224-63-1

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General Information

  • CAS No. 6224-63-1
  • Cat. No. CS-W012100
  • Purity ≥97%
  • MDL No. MFCD00008532
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₂₁P
  • Molecular Weight 304.37
  • Synonym(s) Tris(3-methylphenyl)phosphine
  • SMILES CC1=CC(P(C2=CC=CC(C)=C2)C3=CC=CC(C)=C3)=CC=C1

Description

Hexamethyldisilazane is used as a solvent in organic synthesis and organometallic chemistry. It is often used as an adhesion promoter for photoresist in photolithography. Further, it is used for the preparation of trimethylsilyl ethers from hydroxy compounds. It is used as an alternative to critical point drying during sample preparation in electron microscopy. It is added to analyte to get silylated diagnostic products during pyrolysis in gas chromatography- mass spectrometry.

Application

Tri-m-tolylphosphine serves as a sterically hindered, bench-stable phosphine ligand that facilitates cross-coupling reactions in palladium-catalyzed processes. Its three meta-tolyl groups provide enhanced oxidative stability and improved solubility in organic media, enabling efficient catalysis in Suzuki-Miyaura, Stille, and Negishi couplings. The ligand exhibits excellent functional group tolerance and simplifies purification due to its low volatility and resistance to air oxidation.

Synthesis

  • Route1
    • null|null
      28987-79-3
    • ~73%
    • In-stock
      Tri-m-tolylphosphine|CS-W012100
      6224-63-1

    References

    • Auburn, Pamela R.; Mackenzie, Peter B.; Bosnich, B. Journal of the American Chemical Society, 1985 , vol. 107, # 7 p. 2033 - 2046
  • Route2
    • null|null
      6151-88-8
    • ~94%
    • In-stock
      Tri-m-tolylphosphine|CS-W012100
      6224-63-1

    References

    • Kawakubo, Hiromu; Kuroboshi, Manabu; Yano, Tomotake; Kobayashi, Kazuma; Kamenoue, Syogo; Akagi, Tomomi; Tanaka, Hideo Synthesis, 2011 , # 24 art. no. F78211SS, p. 4091 - 4098
  • Route3
    • null|null
      373623-33-7
    • ~64%
    • In-stock
      Tri-m-tolylphosphine|CS-W012100
      6224-63-1

    References

    • Le Gall, Erwan; Ben Aissi, Karima; Lachaise, Isabelle; Troupel, Michel Synlett, 2006 , # 6 p. 954 - 956

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   4.37006
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   3

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