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CS-W001157 4
Total: USD 88.00

Tris(3,5-dimethylphenyl)phosphine

  • CAS No. 69227-47-0

  • Cat. No. CS-W013910
  • Purity≥95%
  • MDL No.MFCD03094579

*For research and further manufacturing use only, not for direct human use.

Tris(3,5-dimethylphenyl)phosphine|CS-W013910

Structure of 69227-47-0

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General Information

  • CAS No. 69227-47-0
  • Cat. No. CS-W013910
  • Purity ≥95%
  • MDL No. MFCD03094579
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₄H₂₇P
  • Molecular Weight 346.45
  • Synonym(s) TRIS(3,5-XYLYL)PHOSPHINE
  • SMILES CC1=CC(C)=CC(P(C2=CC(C)=CC(C)=C2)C3=CC(C)=CC(C)=C3)=C1

Application

Tris(3,5-dimethylphenyl)phosphine serves as a sterically hindered, electron-rich phosphine ligand that enables efficient cross-coupling reactions under mild conditions. Its robustness and stability enhance catalytic performance in palladium-catalyzed transformations, particularly in Suzuki-Miyaura and Negishi couplings. The bulky 3,5-dimethylphenyl groups provide excellent steric protection, minimizing catalyst deactivation while maintaining high reactivity in challenging substrates. This ligand facilitates reliable product formation with broad functional group tolerance and simplifies purification due to its low volatility and resistance to oxidation.

Synthesis

  • Route1
    • null|null
      34696-73-6
    • ~53%
    • In-stock
      Tris(3,5-dimethylphenyl)phosphine|CS-W013910
      69227-47-0

    References

    • Culcasi, Marcel; Berchadsky, Yves; Gronchi, Gerard; Tordo, Paul Journal of Organic Chemistry, 1991 , vol. 56, # 11 p. 3537 - 3542
  • Route2

    References

    • Tetrahedron Letters, , vol. 44, # 23 p. 4379 - 4383
  • Route3
    • null|null
      108-69-0
    • ~%
    • In-stock
      Tris(3,5-dimethylphenyl)phosphine|CS-W013910
      69227-47-0

    References

    • Tetrahedron Asymmetry, , vol. 15, # 11 p. 1673 - 1676

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   5.29532
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   3

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