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CS-W001157 4
Total: USD 88.00

MePhos

  • CAS No. 251320-86-2

  • Cat. No. CS-W009778
  • Purity≥97%
  • MDL No.MFCD03094577

*For research and further manufacturing use only, not for direct human use.

MePhos|CS-W009778

Structure of 251320-86-2

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General Information

  • CAS No. 251320-86-2
  • Cat. No. CS-W009778
  • Purity ≥97%
  • MDL No. MFCD03094577
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₅H₃₃P
  • Molecular Weight 364.50
  • Synonym(s) None
  • SMILES CC1=C(C=CC=C1)C2=C(P(C3CCCCC3)C4CCCCC4)C=CC=C2

Application

MePhos serves as a robust, bench-stable phosphine ligand in palladium-catalyzed cross-coupling reactions. Its electron-rich character enhances reactivity in challenging coupling transformations, particularly with sterically hindered substrates. The ligand exhibits excellent functional group tolerance and facilitates efficient catalyst turnover, enabling reliable yields in Suzuki, Stille, and Negishi couplings. MePhos is valued for its ease of handling, stability under ambient conditions, and compatibility with scale-up processes.

Synthesis

  • Route1
    • 2-Bromo-2'-methyl-1,1'-biphenyl|CS-1696867
      251320-87-3
    • null|null
      16523-54-9
    • ~65%
    • In-stock
      MePhos|CS-W009778
      251320-86-2

    References

    • Wolfe, John P.; Singer, Robert A.; Yang, Bryant H.; Buchwald, Stephen L. Journal of the American Chemical Society, 1999 , vol. 121, # 41 p. 9550 - 9561
  • Route2
    • In-stock
      1-Bromo-2-chlorobenzene|CS-W004051
      694-80-4
    • null|null
      33872-80-9
    • null|null
      16523-54-9
    • ~49%
    • In-stock
      MePhos|CS-W009778
      251320-86-2

    References

    • Kaye, Steven; Fox, Joseph M.; Hicks, Frederick A.; Buchwald, Stephen L. Advanced Synthesis and Catalysis, 2001 , vol. 343, # 8 p. 789 - 794
  • Route3
    • null|null
      19493-31-3
    • null|null
      16523-54-9
    • ~53%
    • In-stock
      MePhos|CS-W009778
      251320-86-2

    References

    • Ullah, Ehsan; McNulty, James; Robertson, Al European Journal of Organic Chemistry, 2012 , # 11 p. 2127 - 2131

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   7.43462
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   4

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