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CS-W001157 4
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2'-(Dicyclohexylphosphino)-N,N-dimethyl[1,1'-biphenyl]-4-amine

  • CAS No. 1185899-00-6

  • Cat. No. CS-0035155
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2'-(Dicyclohexylphosphino)-N,N-dimethyl[1,1'-biphenyl]-4-amine|CS-0035155

Structure of 1185899-00-6

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General Information

  • CAS No. 1185899-00-6
  • Cat. No. CS-0035155
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₆H₃₆NP
  • Molecular Weight 393.54
  • Synonym(s) 2-Dicyclohexylphosphino-4-(N,N-dimethylamino)-1,1'-biphenyl
  • SMILES CN(C)C1=CC=C(C=C1)C2=CC=CC=C2P(C3CCCCC3)C4CCCCC4

Description

This diphosphine amine integrates a sterically shielded dicyclohexylphosphino group with a dimethylamino-substituted biphenyl scaffold, delivering enhanced stability and selective coordination in palladium-catalyzed cross-coupling reactions.

Application

2'-(Dicyclohexylphosphino)-N,N-dimethyl[1,1'-biphenyl]-4-amine serves as a highly effective ligand in palladium-catalyzed cross-coupling reactions, enabling efficient C–C and C–heteroatom bond formation under mild conditions. Its steric bulk and electron-rich character enhance catalyst stability and turnover, particularly in challenging substrates. The dimethylamino group improves solubility and facilitates purification, while the dicyclohexylphosphino moiety ensures robust performance across Suzuki, Stille, and Negishi couplings.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   3.24
  • LogP   7.1922
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   5

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