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CS-W001157 4
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2-Diphenylphosphino-2',6'-bis(dimethylamino)-1,1'-biphenyl

  • CAS No. 1447963-71-4

  • Cat. No. CS-0088281
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Diphenylphosphino-2',6'-bis(dimethylamino)-1,1'-biphenyl|CS-0088281

Structure of 1447963-71-4

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General Information

  • CAS No. 1447963-71-4
  • Cat. No. CS-0088281
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₈H₂₉N₂P
  • Molecular Weight 424.52
  • Synonym(s) phosphino-2',6'-bis(dimethyL
  • SMILES CN(C)C1=CC=CC(N(C)C)=C1C2=C(P(C3=CC=CC=C3)C4=CC=CC=C4)C=CC=C2

Description

This bidentate phosphine ligand features a diphenylphosphino group paired with electron-donating dimethylamino substituents at the 2' and 6' positions, enhancing its electron density and stability. The rigid biphenyl backbone promotes efficient metal coordination, making it ideal for palladium-catalyzed cross-coupling reactions under mild conditions.

Application

2-Diphenylphosphino-2',6'-bis(dimethylamino)-1,1'-biphenyl serves as a highly effective, bench-stable ligand in palladium-catalyzed cross-coupling reactions. Its electron-rich phosphine center and sterically protected architecture enable efficient coupling of aryl halides with boron nucleophiles, facilitating reliable C–C bond formation under mild conditions. The dimethylamino substituents enhance solubility and electronic donation, improving catalyst turnover and functional group tolerance in complex molecule synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   6.48
  • LogP   5.2438
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   6

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