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CS-W001157 4
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(4R,4'R)-2,2'-methylenebis[4,5-dihydro-4-(1-methylethyl)oxazole]

  • CAS No. 164976-63-0

  • Cat. No. CS-0113768
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4R,4'R)-2,2'-methylenebis[4,5-dihydro-4-(1-methylethyl)oxazole]|CS-0113768

Structure of 164976-63-0

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General Information

  • CAS No. 164976-63-0
  • Cat. No. CS-0113768
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₂N₂O₂
  • Molecular Weight 238.33
  • Synonym(s) 2,2'-methylenebis[(4S)-4-isopropyl-2-oxazoline
  • SMILES CC(C)[C@@H]1COC(CC2=N[C@H](C(C)C)CO2)=N1

Description

This chiral bis-oxazole scaffold delivers high stereochemical fidelity and structural rigidity, enabling precise molecular positioning in asymmetric synthesis. Its methylene-bridged architecture enhances conformational stability while maintaining compatibility with diverse reaction conditions.

Application

(4R,4'R)-2,2'-methylenebis[4,5-dihydro-4-(1-methylethyl)oxazole] serves as a chiral bis-oxazoline ligand enabling efficient asymmetric catalysis in transition-metal-mediated reactions. Its rigid methylene-bridged structure provides excellent stereocontrol and stability under standard reaction conditions. The isopropyl-substituted oxazole rings exhibit high functional group tolerance and facilitate straightforward purification, making it well-suited for scalable synthesis applications in enantioselective transformations.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   43.18
  • LogP   2.2831
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   4

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