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CS-W001157 4
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Bis((R)-4-methyl-4,5-dihydrooxazol-2-yl)methane

  • CAS No. 2757082-29-2

  • Cat. No. CS-0179448
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Bis((R)-4-methyl-4,5-dihydrooxazol-2-yl)methane|CS-0179448

Structure of 2757082-29-2

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General Information

  • CAS No. 2757082-29-2
  • Cat. No. CS-0179448
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₄N₂O₂
  • Molecular Weight 182.22
  • Synonym(s) None
  • SMILES C[C@H](CO1)N=C1CC2=N[C@H](C)CO2

Description

Bis((R)-4-methyl-4,5-dihydrooxazol-2-yl)methane is a chiral bisoxazoline ligand featuring two (R)-configured 4-methyl-4,5-dihydrooxazol-2-yl groups linked by a methylene bridge. This structure delivers high enantioselectivity in transition metal-catalyzed asymmetric reactions, particularly in copper- and palladium-mediated processes. The molecule exhibits excellent bench stability and compatibility with standard reaction conditions.

Application

Bis((R)-4-methyl-4,5-dihydrooxazol-2-yl)methane serves as a chiral auxiliary in asymmetric synthesis, enabling stereoselective transformations through its rigid, enantiomerically pure oxazoline framework. The molecule exhibits excellent bench stability and facilitates efficient functional group manipulation, making it well-suited for iterative coupling strategies and the construction of complex heterocyclic scaffolds in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   43.18
  • LogP   1.0109
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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