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CS-W001157 4
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Bis((S)-4-isobutyl-4,5-dihydrooxazol-2-yl)methane

  • CAS No. 176650-25-2

  • Cat. No. CS-0610804
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Bis((S)-4-isobutyl-4,5-dihydrooxazol-2-yl)methane|CS-0610804

Structure of 176650-25-2

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General Information

  • CAS No. 176650-25-2
  • Cat. No. CS-0610804
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₆N₂O₂
  • Molecular Weight 266.38
  • Synonym(s) None
  • SMILES CC(C)C[C@H]1COC(CC2=N[C@@H](CC(C)C)CO2)=N1

Description

Bis((S)-4-isobutyl-4,5-dihydrooxazol-2-yl)methane features two chiral oxazoline rings flanking a methylene bridge, delivering high stereochemical fidelity. This bench-stable ligand integrates readily into asymmetric catalysis, enabling efficient enantioselective transformations under mild conditions.

Application

Bis((S)-4-isobutyl-4,5-dihydrooxazol-2-yl)methane serves as a chiral bis-oxazoline ligand that enables asymmetric transition-metal-catalyzed reactions, particularly in enantioselective C–C bond formation. Its rigid, well-defined chiral pocket and robust bench stability facilitate high enantioselectivity in catalytic processes. The isobutyl substituent enhances solubility and steric differentiation, while the dihydrooxazoline rings offer excellent functional group tolerance and ease of purification, making it a reliable choice for synthetic applications requiring stereocontrol.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   43.18
  • LogP   3.0633
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   6

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