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CS-W001157 4
Total: USD 88.00

4,4'-Bipiperidine

  • CAS No. 15336-72-8

  • Cat. No. CS-0155215
  • Purity≥97%
  • MDL No.MFCD01104315

*For research and further manufacturing use only, not for direct human use.

4,4'-Bipiperidine|CS-0155215

Structure of 15336-72-8

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General Information

  • CAS No. 15336-72-8
  • Cat. No. CS-0155215
  • Purity ≥97%
  • MDL No. MFCD01104315
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₀N₂
  • Molecular Weight 168.28
  • Synonym(s) [4,4']Bipiperidinyl
  • SMILES C1CNCCC1C2CCNCC2

Description

4,4'-Bipiperidine is a rigid, electron-rich dipyridyl scaffold featuring two piperidine rings linked at their 4-positions. This structural motif provides enhanced conformational stability and improved solubility in polar solvents compared to related heterocycles. The molecule integrates readily into pharmaceutical intermediates, where its basic nitrogen atoms facilitate salt formation and modulate pharmacokinetic properties. Its well-defined steric profile supports selective binding in target-directed synthesis.

Application

4,4'-Bipiperidine serves as a versatile bis-heterocyclic scaffold in medicinal chemistry, enabling the construction of rigid, multi-donor systems for target engagement. Its robust bench stability and orthogonal reactivity support efficient functionalization at both nitrogen centers, facilitating downstream derivatization in ligand design. The molecule functions effectively as a core building block in the synthesis of bioactive compounds, particularly those requiring extended pharmacophores with controlled conformational flexibility.

Synthesis

  • Route1

    References

    • Journal of Medicinal Chemistry, , vol. 48, # 20 p. 6491 - 6503
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 50, p. 1937
  • Route3
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      110-86-1
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    • In-stock
      4,4'-Bipiperidine|CS-0155215
      15336-72-8

    References

    • Journal of the Chemical Society, , p. 3872 Zhurnal Obshchei Khimii, , vol. 3, p. 351,353 Chem. Zentralbl., , vol. 105, # II p. 443 Yakugaku Zasshi, , vol. 62, p. 241,245; dtsch. Ref. S. 61, 63, 65 Chem.Abstr., , p. 5150

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   24.06
  • LogP   0.9856
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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