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CS-W001157 4
Total: USD 88.00

(R,R)-Ph-Bisbox

  • CAS No. 148925-98-8

  • Cat. No. CS-0097379
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(R,R)-Ph-Bisbox|CS-0097379

Structure of 148925-98-8

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General Information

  • CAS No. 148925-98-8
  • Cat. No. CS-0097379
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₁₆N₂O₂
  • Molecular Weight 292.33
  • Synonym(s) (4R,4'R)-4,4'-Diphenyl-4,4',5,5'-tetrahydro-2,2'-bioxazole
  • SMILES C1(C2=N[C@H](C3=CC=CC=C3)CO2)=N[C@H](C4=CC=CC=C4)CO1

Description

(R,R)-Ph-Bisbox is a chiral bis(oxazoline) ligand featuring two phenyl-substituted oxazoline rings, designed for asymmetric catalysis. This bench-stable, moisture-tolerant scaffold delivers high enantioselectivity in transition metal-catalyzed reactions, particularly in aldol and cycloaddition processes. Its rigid, well-defined coordination geometry enables precise stereocontrol.

Application

(R,R)-Ph-Bisbox serves as a highly effective chiral ligand in asymmetric catalysis, enabling enantioselective transformations through well-established coordination with transition metals. Its rigid bis(oxazoline) architecture provides excellent stereocontrol in reactions such as cycloadditions and metal-catalyzed alkylations. The phenyl-substituted backbone enhances stability and solubility, facilitating straightforward handling and purification in synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.18
  • LogP   3.3264
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   3

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