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CS-W001157 4
Total: USD 88.00

(S,S)-Ph-Bisbox

  • CAS No. 135532-33-1

  • Cat. No. CS-0097374
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S,S)-Ph-Bisbox|CS-0097374

Structure of 135532-33-1

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General Information

  • CAS No. 135532-33-1
  • Cat. No. CS-0097374
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₁₆N₂O₂
  • Molecular Weight 292.33
  • Synonym(s) (4S,4'S)-4,4'-diphenyl-4,4',5,5'-tetrahydro-2,2'-bioxazole
  • SMILES C1(C2=N[C@@H](C3=CC=CC=C3)CO2)=N[C@@H](C4=CC=CC=C4)CO1

Description

(S,S)-Ph-Bisbox is a chiral bis(oxazoline) ligand featuring two phenyl-substituted oxazoline rings, designed for asymmetric catalysis. This bench-stable, moisture-tolerant scaffold delivers high enantioselectivity in transition metal-catalyzed reactions, particularly in allylation and cycloaddition processes. Its rigid, well-defined coordination geometry enables precise stereocontrol.

Application

(S,S)-Ph-Bisbox serves as a highly effective chiral ligand in asymmetric catalysis, enabling enantioselective transformations through well-established coordination modes with transition metals. Its robust bench stability and predictable stereocontrol facilitate reliable synthesis of chiral building blocks for pharmaceutical intermediates. The ligand exhibits excellent functional group tolerance and simplifies purification in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.18
  • LogP   3.3264
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   3

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