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CS-W001157 4
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Mal-PEG3-NHS ester

  • CAS No. 1537892-36-6

  • Cat. No. CS-0106353
  • Purity≥95%
  • MDL No.MFCD26127782

*For research and further manufacturing use only, not for direct human use.

Mal-PEG3-NHS ester|CS-0106353

Structure of 1537892-36-6

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General Information

  • CAS No. 1537892-36-6
  • Cat. No. CS-0106353
  • Purity ≥95%
  • MDL No. MFCD26127782
  • Storage -20°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₂₂N₂O₉
  • Molecular Weight 398.36
  • Synonym(s) None
  • SMILES O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCN2C(C=CC2=O)=O

Description

Mal-PEG3-NHS ester is a bifunctional crosslinker featuring a maleimide group conjugated to a PEG spacer and an NHS ester terminus. This compound enables site-specific bioconjugation via thiol-Michael addition at the maleimide end, while the NHS ester facilitates amine coupling under physiological conditions. The PEG3 spacer provides enhanced solubility and reduced steric hindrance, improving reaction efficiency in protein labeling and antibody-drug conjugate synthesis.

Application

Mal-PEG3-NHS ester serves as a versatile bifunctional crosslinker, enabling efficient conjugation of biomolecules via amine-reactive NHS ester and maleimide-thiol ligation. The PEG3 spacer provides enhanced solubility and reduced steric hindrance, facilitating reliable labeling in aqueous environments. Its stability under physiological conditions and high selectivity for thiol groups make it ideal for site-specific bioconjugation workflows in antibody-drug conjugate development and protein modification.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P405-P501

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Computational Chemistry Data

  • TPSA   128.75
  • LogP   -1.0415
  • H_Acceptors   9
  • H_Donors   0
  • Rotatable_Bonds   13

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