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CS-W001157 4
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Mal-PEG2-NHS ester

  • CAS No. 1433997-01-3

  • Cat. No. CS-0105019
  • Purity≥95%
  • MDL No.MFCD24539465

*For research and further manufacturing use only, not for direct human use.

Mal-PEG2-NHS ester|CS-0105019

Structure of 1433997-01-3

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General Information

  • CAS No. 1433997-01-3
  • Cat. No. CS-0105019
  • Purity ≥95%
  • MDL No. MFCD24539465
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₈N₂O₈
  • Molecular Weight 354.31
  • Synonym(s) None
  • SMILES O=C(ON1C(CCC1=O)=O)CCOCCOCCN2C(C=CC2=O)=O

Description

Mal-PEG2-NHS ester is a bifunctional crosslinker featuring a maleimide group for selective thiol conjugation and a NHS ester for amine reactivity. This PEG2 spacer provides enhanced solubility and reduced steric hindrance, enabling efficient bioconjugation in aqueous environments.

Application

Mal-PEG2-NHS ester serves as a versatile bifunctional linker for protein conjugation and biomolecule labeling. The maleimide group enables selective, site-specific thiol-addition under physiological conditions, while the PEG2 spacer provides enhanced solubility and reduced steric hindrance. The NHS ester reacts efficiently with primary amines (e.g., lysine residues or N-termini), facilitating dual-functionalization strategies in antibody-drug conjugate development and bioconjugation workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   119.52
  • LogP   -1.0581
  • H_Acceptors   8
  • H_Donors   0
  • Rotatable_Bonds   10

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